Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively

AIMS/HYPOTHESIS: Genome-wide association (GWA) studies have identified hundreds of common genetic variants associated with obesity and type 2 diabetes. These studies have usually focused on additive association tests. Identifying deviations from additivity may provide new biological insights and exp...

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Veröffentlicht in:Diabetologia
Hauptverfasser: Wood, Andrew R., Tyrrell, Jessica, Beaumont, Robin, Jones, Samuel E., Tuke, Marcus A., Ruth, Katherine S., Yaghootkar, Hanieh, Freathy, Rachel M., Murray, Anna, Frayling, Timothy M., Weedon, Michael N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869698/
https://ncbi.nlm.nih.gov/pubmed/26961502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-3908-5
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