Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health

STUDY QUESTION: How does a genetic variant in the FSHB promoter, known to alter FSH levels, impact female reproductive health? SUMMARY ANSWER: The T allele of the FSHB promoter polymorphism (rs10835638; c.-211G>T) results in longer menstrual cycles and later menopause and, while having detrimenta...

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Publicado en:Hum Reprod
Autores principales: Ruth, Katherine S., Beaumont, Robin N., Tyrrell, Jessica, Jones, Samuel E., Tuke, Marcus A., Yaghootkar, Hanieh, Wood, Andrew R., Freathy, Rachel M., Weedon, Michael N., Frayling, Timothy M., Murray, Anna
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716809/
https://ncbi.nlm.nih.gov/pubmed/26732621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/dev318
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