Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation

BACKGROUND: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in the DNA damage response pathway. The aim of this...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Baert, Annelot, Depuydt, Julie, Van Maerken, Tom, Poppe, Bruce, Malfait, Fransiska, Storm, Katrien, van den Ende, Jenneke, Van Damme, Tim, De Nobele, Sylvia, Perletti, Gianpaolo, De Leeneer, Kim, Claes, Kathleen B. M., Vral, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869288/
https://ncbi.nlm.nih.gov/pubmed/27184744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-016-0709-1
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