miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis

The ability of the unfolded protein response, UPR, to regulate cell homeostasis through both gene expression and protein synthesis has been well documented. One primary pro-apoptotic protein that responds to both PERK and Ire1 signalling is the CHOP/GADD153 transcription factor. Although CHOP defici...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Xu, Zhenhua, Bu, Yiwen, Chitnis, Nilesh, Koumenis, Costas, Fuchs, Serge Y., Diehl, J. Alan
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869177/
https://ncbi.nlm.nih.gov/pubmed/27173017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11422
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