Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide

IL-17A is a pro-inflammatory cytokine that has been implicated in autoimmune and inflammatory diseases. Monoclonal antibodies inhibiting IL-17A signaling have demonstrated remarkable efficacy, but an oral therapy is still lacking. A high affinity IL-17A peptide antagonist (HAP) of 15 residues was id...

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Publicado no:Sci Rep
Main Authors: Liu, Shenping, Desharnais, Joel, Sahasrabudhe, Parag V., Jin, Ping, Li, Wei, Oates, Bryan D., Shanker, Suman, Banker, Mary Ellen, Chrunyk, Boris A., Song, Xi, Feng, Xidong, Griffor, Matt, Jimenez, Judith, Chen, Gang, Tumelty, David, Bhat, Abhijit, Bradshaw, Curt W., Woodnutt, Gary, Lappe, Rodney W., Thorarensen, Atli, Qiu, Xiayang, Withka, Jane M., Wood, Lauren D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869123/
https://ncbi.nlm.nih.gov/pubmed/27184415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26071
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