Double Dissociation of Monoacylglycerol Lipase Inhibition and CB(1) Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats

Both CB(1) receptor antagonism and agonism, in particular by 2-arachidonyl glycerol (2-AG), have been shown to reduce somatic symptoms of morphine withdrawal (MWD). Here we evaluated the effects of both systemic pretreatment with the monoacylglycerol lipase (MAGL) inhibitor MJN110 (which selectively...

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Publicado en:Neuropsychopharmacology
Autores principales: Wills, Kiri L, Petrie, Gavin N, Millett, Geneva, Limebeer, Cheryl L, Rock, Erin M, Niphakis, Micah J, Cravatt, Benjamin F, Parker, Linda A
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869055/
https://ncbi.nlm.nih.gov/pubmed/26647976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.356
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