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eIF4A moonlights as an off switch for TORC1
TORC1 is actively inhibited upon amino acid withdrawal. Tsokanos et al (2016) shed light on the underlying molecular mechanism. They demonstrate that upon removal of exogenous amino acids, eIF4A inhibits TORC1 via TSC2. Thus, whereas it is well known that TORC1 regulates the translation machinery, w...
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| Izdano u: | EMBO J |
|---|---|
| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868953/ https://ncbi.nlm.nih.gov/pubmed/27044920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694326 |
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