Generation and characterization of a tetraspanin CD151/integrin α6β1-binding domain competitively binding monoclonal antibody for inhibition of tumor progression in HCC

Our previous studies revealed that tetraspanin CD151 plays multiple roles in the progression of hepatocellular carcinoma (HCC) by forming a functional complex with integrin α6β1. Herein, we generated a monoclonal antibody (mAb) that dissociates the CD151/integrin α6β1 complex, and we evaluated its b...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Ke, Ai-Wu, Zhang, Peng-Fei, Shen, Ying-Hao, Gao, Ping-Ting, Dong, Zhao-Ru, Zhang, Chi, Cai, Jia-Bin, Huang, Xiao-Yong, Wu, Chao, Zhang, Lu, Kang, Qiang, Liu, Li-Xin, Xie, Nan, Shen, Zao-Zhuo, Hu, Mei-Yu, Cao, Ya, Qiu, Shuang-Jian, Sun, Hui-Chuan, Zhou, Jian, Fan, Jia, Shi, Guo-Ming
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868758/
https://ncbi.nlm.nih.gov/pubmed/26756217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6833
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