BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients

Androgen receptor (AR) mutations arise in patients developing resistance to hormone deprivation therapies. Here we describe BAY 1024767, a thiohydantoin derivative with strong antagonistic activity against nine AR variants with mutations located in the AR ligand-binding domain (LBD), and against wil...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Sugawara, Tatsuo, Lejeune, Pascale, Köhr, Silke, Neuhaus, Roland, Faus, Hortensia, Gelato, Kathy A., Busemann, Matthias, Cleve, Arwed, Lücking, Ulrich, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Jung, Klaus, Stephan, Carsten, Haendler, Bernard
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868737/
https://ncbi.nlm.nih.gov/pubmed/26760770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6864
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