Synergistic effect of therapeutic stem cells expressing cytosine deaminase and interferon-beta via apoptotic pathway in the metastatic mouse model of breast cancer

As an approach to improve treatment of breast cancer metastasis to the brain, we employed genetically engineered stem cells (GESTECs, HB1.F3 cells) consisting of neural stem cells (NSCs) expressing cytosine deaminase and the interferon-beta genes, HB1.F3.CD and HB1.F3.CD.IFN-β. In this model, MDA-MB...

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Vydáno v:Oncotarget
Hlavní autoři: Yi, Bo-Rim, Kim, Seung U., Choi, Kyung-Chul
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868735/
https://ncbi.nlm.nih.gov/pubmed/26716512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6719
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