Tubeimoside-1 suppresses tumor angiogenesis by stimulation of proteasomal VEGFR2 and Tie2 degradation in a non-small cell lung cancer xenograft model

Tubeimoside-1 (TBMS1) is a potent anti-tumor phytochemical. Its functional and molecular mode of action, however, remains elusive so far. Since angiogenesis is essential for tumor progression and metastasis, we herein investigated the anti-angiogenic effects of the compound. In a non-small cell lung...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Gu, Yuan, Körbel, Christina, Scheuer, Claudia, Nenicu, Anca, Menger, Michael D., Laschke, Matthias W.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868684/
https://ncbi.nlm.nih.gov/pubmed/26701724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6676
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