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BAFF promotes autoantibody production via TACI-dependent activation of transitional B cells

Mice overexpressing B cell activating factor of the TNF family (BAFF) develop systemic autoimmunity characterized by class-switched anti-nuclear antibodies. Transmembrane activator and CAML interactor (TACI) signals are critical for BAFF-mediated autoimmunity, but the B cell developmental subsets un...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Jacobs, Holly M., Thouvenel, Christopher D., Leach, Sarah, Arkatkar, Tanvi, Metzler, Genita, Scharping, Nicole E., Kolhatkar, Nikita S., Rawlings, David J., Jackson, Shaun W.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868625/
https://ncbi.nlm.nih.gov/pubmed/27022196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600017
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