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δ-COP modulates Aβ peptide formation via retrograde trafficking of APP

The components involved in cellular trafficking and protein recycling machinery that have been associated with increased Alzheimer’s disease (AD) risk belong to the late secretory compartments for the most part. Here, we hypothesize that these late unavoidable events might be the consequence of earl...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bettayeb, Karima, Chang, Jerry C., Luo, Wenjie, Aryal, Suvekshya, Varotsis, Dante, Randolph, Lisa, Netzer, William J., Greengard, Paul, Flajolet, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868462/
https://ncbi.nlm.nih.gov/pubmed/27114525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604156113
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