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SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A
In order to expand the repertoire of antifungal compounds a novel, high-throughput phenotypic drug screen targeting fungal phosphatidylserine (PS) synthase (Cho1p) was developed based on antagonism of the toxin papuamide A (Pap-A). Pap-A is a cyclic depsipeptide that binds to PS in the membrane of w...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868317/ https://ncbi.nlm.nih.gov/pubmed/27183222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154932 |
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