Targeting CXCR1/2 Significantly Reduces Breast Cancer Stem Cell Activity and Increases the Efficacy of Inhibiting HER2 via HER2-dependent and -independent Mechanisms

PURPOSE: Breast cancer stem-like cells (CSCs) are an important therapeutic target as they are predicted to be responsible for tumour initiation, maintenance and metastases. Interleukin-8 (IL-8) is upregulated in breast cancer and associated with poor prognosis. Breast cancer cell line studies indica...

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Publicado en:Clin Cancer Res
Main Authors: Singh, Jagdeep K., Farnie, Gillian, Bundred, Nigel J., Simões, Bruno M, Shergill, Amrita, Landberg, Göran, Howell, Sacha, Clarke, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868141/
https://ncbi.nlm.nih.gov/pubmed/23149820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1063
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