Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity

INTRODUCTION: Exogenous prolactin is mitogenic and antiapoptotic in breast cancer cells, and overexpression of autocrine prolactin cDNA in breast cancer cell lines has been shown to stimulate their growth and to protect against chemotherapy-induced apoptosis. We examined the effects of the 'pur...

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Détails bibliographiques
Auteurs principaux: Howell, Sacha J, Anderson, Elizabeth, Hunter, Tom, Farnie, Gillian, Clarke, Robert B
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2008
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575541/
https://ncbi.nlm.nih.gov/pubmed/18681966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2129
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