Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4α and PPARα

Cytochrome P450 1b1 (Cyp1b1) is expressed in endothelia, stellate cells and pre-adipocytes, but not hepatocytes. Deletion alters liver fatty acid metabolism and prevents obesity and hepatic steatosis. This suggests a novel extra-hepatocyte regulation directed from cells that express Cyp1b1. To chara...

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Bibliographische Detailangaben
Veröffentlicht in:Arch Biochem Biophys
Hauptverfasser: Bushkofsky, Justin R., Maguire, Meghan, Larsen, Michele Campaigne, Fong, Yee Hoon, Jefcoate, Colin R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868071/
https://ncbi.nlm.nih.gov/pubmed/27036855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.03.030
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