Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development

BACKGROUND: Cytochrome P450 1b1 (Cyp1b1) deletion and dietary retinol deficiency during pregnancy (GVAD) affect perinatal liver functions regulated by Srebp. Cyp1b1 is not expressed in perinatal liver but appears in the E9.5 embryo, close to sites of retinoic acid (RA) signaling. HYPOTHESIS: Paralle...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Maguire, Meghan, Larsen, Michele Campaigne, Vezina, Chad M., Quadro, Loredana, Kim, Youn-Kyung, Tanumihardjo, Sherry A., Jefcoate, Colin R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004353/
https://ncbi.nlm.nih.gov/pubmed/32027669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228436
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