Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development

BACKGROUND: Cytochrome P450 1b1 (Cyp1b1) deletion and dietary retinol deficiency during pregnancy (GVAD) affect perinatal liver functions regulated by Srebp. Cyp1b1 is not expressed in perinatal liver but appears in the E9.5 embryo, close to sites of retinoic acid (RA) signaling. HYPOTHESIS: Paralle...

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Publicat a:PLoS One
Autors principals: Maguire, Meghan, Larsen, Michele Campaigne, Vezina, Chad M., Quadro, Loredana, Kim, Youn-Kyung, Tanumihardjo, Sherry A., Jefcoate, Colin R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004353/
https://ncbi.nlm.nih.gov/pubmed/32027669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228436
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