Preventive and chronic mineralocorticoid receptor antagonism is highly beneficial in obese SHHF rats

BACKGROUND AND PURPOSE: Mineralocorticoid receptor (MR) activation contributes to heart failure (HF) progression. Its overactivity in obesity is thought to accelerate cardiac remodelling and HF development. Given that MR antagonists (MRA) are beneficial in chronic HF patients, we hypothesized that e...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Youcef, G, Olivier, A, Nicot, N, Muller, A, Deng, C, Labat, C, Fay, R, Rodriguez‐Guéant, R‐M, Leroy, C, Jaisser, F, Zannad, F, Lacolley, P, Vallar, L, Pizard, A
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867740/
https://ncbi.nlm.nih.gov/pubmed/26990406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13479
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