Preventive and chronic mineralocorticoid receptor antagonism is highly beneficial in obese SHHF rats

BACKGROUND AND PURPOSE: Mineralocorticoid receptor (MR) activation contributes to heart failure (HF) progression. Its overactivity in obesity is thought to accelerate cardiac remodelling and HF development. Given that MR antagonists (MRA) are beneficial in chronic HF patients, we hypothesized that e...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Youcef, G, Olivier, A, Nicot, N, Muller, A, Deng, C, Labat, C, Fay, R, Rodriguez‐Guéant, R‐M, Leroy, C, Jaisser, F, Zannad, F, Lacolley, P, Vallar, L, Pizard, A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867740/
https://ncbi.nlm.nih.gov/pubmed/26990406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13479
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