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Endothelial SK3 channel-associated Ca(2+) microdomains modulate blood pressure

Activation of vascular endothelial small- (K(Ca)2.3, SK3) or intermediate- (K(Ca)3.1, IK1) conductance Ca(2+)-activated potassium channels induces vasorelaxation via an endothelium-derived hyperpolarization (EDH) pathway. Although the activation of SK3 and IK1 channels converges on EDH, their subcel...

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Détails bibliographiques
Publié dans:Am J Physiol Heart Circ Physiol
Auteurs principaux: Yap, Fui C., Weber, David S., Taylor, Mark S., Townsley, Mary I., Comer, Brian S., Maylie, James, Adelman, John P., Lin, Mike T.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867388/
https://ncbi.nlm.nih.gov/pubmed/26945080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00787.2015
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