Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology

Low-grade neuroepithelial tumors (LGNTs) are diverse CNS tumors presenting in children and young adults, often with a history of epilepsy. While the genetic profiles of common LGNTs, such as the pilocytic astrocytoma and ‘adult-type’ diffuse gliomas, are largely established, those of uncommon LGNTs...

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Published in:Acta Neuropathol
Main Authors: Qaddoumi, Ibrahim, Orisme, Wilda, Wen, Ji, Santiago, Teresa, Gupta, Kirti, Dalton, James D., Tang, Bo, Haupfear, Kelly, Punchihewa, Chandanamali, Easton, John, Mulder, Heather, Boggs, Kristy, Shao, Ying, Rusch, Michael, Becksfort, Jared, Gupta, Pankaj, Wang, Shuoguo, Lee, Ryan P., Brat, Daniel, Collins, V. Peter, Dahiya, Sonika, George, David, Konomos, William, Kurian, Kathreena M., McFadden, Kathryn, Serafini, Luciano Neder, Nickols, Hilary, Perry, Arie, Shurtleff, Sheila, Gajjar, Amar, Boop, Fredrick A., Klimo, Paul D., Mardis, Elaine R., Wilson, Richard K., Baker, Suzanne J., Zhang, Jinghui, Wu, Gang, Downing, James R., Tatevossian, Ruth G., Ellison, David W.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866893/
https://ncbi.nlm.nih.gov/pubmed/26810070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1539-z
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