Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth

BACKGROUND: We previously developed and validated a strategy for stimulating heart regeneration by administration of recombinant neuregulin (rNRG1), a growth factor, in mice. rNRG1 stimulated proliferation of heart muscle cells, cardiomyocytes, and was most effective when administration began during...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Ganapathy, Balakrishnan, Nandhagopal, Nikitha, Polizzotti, Brian D., Bennett, David, Asan, Alparslan, Wu, Yijen, Kühn, Bernhard
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866786/
https://ncbi.nlm.nih.gov/pubmed/27175488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155456
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