Losartan Attenuates Myocardial Endothelial-To-Mesenchymal Transition in Spontaneous Hypertensive Rats via Inhibiting TGF-β/Smad Signaling

BACKGROUND: Losartan plays an important role in the inhibition of myocardial fibrosis. But the underlying mechanism is not entirely clear. Emerging evidences have indicated that endothelial-to-mesenchymal transition (EndMT) plays a crucial role in cardiac fibrosis. Here the present study aims to fir...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wu, Miao, Peng, Zhenyu, Zu, Changhao, Ma, Jing, Lu, Shijuan, Zhong, Jianghua, Zhang, Saidan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866756/
https://ncbi.nlm.nih.gov/pubmed/27176484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155730
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