Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase

Bifunctional dihydrofolate reductase–thymidylate synthase (DHFR-TS) is a chemically and genetically validated target in African trypanosomes, causative agents of sleeping sickness in humans and nagana in cattle. Here we report the kinetic properties and sensitivity of recombinant enzyme to a range o...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Negl Trop Dis
Egile Nagusiak: Gibson, Marc W., Dewar, Simon, Ong, Han B., Sienkiewicz, Natasha, Fairlamb, Alan H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866688/
https://ncbi.nlm.nih.gov/pubmed/27175479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004714
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