A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells

Glioblastomas are the most common primary brain tumors, highly vascularized, infiltrating, and resistant to current therapies. This cancer leads to a fatal outcome in less than 18 months. The aggressive behavior of glioblastomas, including resistance to current treatments and tumor recurrence, has b...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Sakakini, Nathalie, Turchi, Laurent, Bergon, Aurélie, Holota, Hélène, Rekima, Samah, Lopez, Fabrice, Paquis, Philipe, Almairac, Fabien, Fontaine, Denys, Baeza-Kallee, Nathalie, Van Obberghen-Schilling, Ellen, Junier, Marie-Pierre, Chneiweiss, Hervé, Figarella-Branger, Dominique, Burel-Vandenbos, Fanny, Imbert, Jean, Virolle, Thierry
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Gene Regulation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865916/
https://ncbi.nlm.nih.gov/pubmed/27002148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.720698
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