Analogues of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) as potential anti-platelet-aggregation agents.

Dense granules of platelets contain a high content of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A). We have previously demonstrated an antithrombotic effect of this compound in a live rabbit model. In the present study we find that certain synthetic Ap4A analogues are superior to Ap4A in inhibiti...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Zamecnik, P C, Kim, B, Gao, M J, Taylor, G, Blackburn, G M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48659/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1549600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.6.2370
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