The small GTPases Ras and Rap1 bind to and control TORC2 activity

Target of Rapamycin Complex 2 (TORC2) has conserved roles in regulating cytoskeleton dynamics and cell migration and has been linked to cancer metastasis. However, little is known about the mechanisms regulating TORC2 activity and function in any system. In Dictyostelium, TORC2 functions at the fron...

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Publicat a:Sci Rep
Autors principals: Khanna, Ankita, Lotfi, Pouya, Chavan, Anita J., Montaño, Nieves M., Bolourani, Parvin, Weeks, Gerald, Shen, Zhouxin, Briggs, Steven P., Pots, Henderikus, Van Haastert, Peter J. M., Kortholt, Arjan, Charest, Pascale G.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865869/
https://ncbi.nlm.nih.gov/pubmed/27172998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25823
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