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Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens

Novel antibacterials are urgently needed to address the growing problem of bacterial resistance to conventional antibiotics. Two-component systems (TCS) are widely used by bacteria to regulate gene expression in response to various environmental stimuli and physiological stress and have been previou...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Velikova, Nadya, Fulle, Simone, Manso, Ana Sousa, Mechkarska, Milena, Finn, Paul, Conlon, J. Michael, Oggioni, Marco Rinaldo, Wells, Jerry M., Marina, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865847/
https://ncbi.nlm.nih.gov/pubmed/27173778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26085
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