SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway

SARS coronavirus (SARS-CoV) papain-like protease (PLpro) has been identified in TGF-β1 up-regulation in human promonocytes (Proteomics 2012, 12: 3193-205). This study investigates the mechanisms of SARS-CoV PLpro-induced TGF-β1 promoter activation in human lung epithelial cells and mouse models. SAR...

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Publicado no:Sci Rep
Main Authors: Li, Shih-Wein, Wang, Ching-Ying, Jou, Yu-Jen, Yang, Tsuey-Ching, Huang, Su-Hua, Wan, Lei, Lin, Ying-Ju, Lin, Cheng-Wen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865725/
https://ncbi.nlm.nih.gov/pubmed/27173006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25754
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