A clinically relevant pharmacokinetic interaction between cyclosporine and imatinib

PURPOSE: Cyclosporine A (CsA) and imatinib are both CYP3A4 and P-glycoprotein substrates. Concomitant use after hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (ALL) may therefore result in a pharmac...

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Bibliographic Details
Published in:Eur J Clin Pharmacol
Main Authors: Atiq, Ferdows, Broers, Annoek E C, Andrews, Louise M, Doorduijn, Jeanette K, Koch, Birgit C P, Van Gelder, Teun, Versmissen, Jorie
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2016
Subjects:
Pharmacokinetics and Disposition
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865545/
https://ncbi.nlm.nih.gov/pubmed/26965514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-016-2038-9
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