Common variation in BRCA1 may play a role in progression to lethal prostate cancer after radiation treatment

PURPOSE: To evaluate if single-nucleotide polymorphisms (SNPs) reflecting common variation in the tumor suppressor BRCA1 affects prostate cancer (CaP) outcomes. Because radiation therapy (RT) induces DNA damage, we hypothesized that common variation in BRCA1 plays a role in progression to lethal CaP...

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Detalhes bibliográficos
Publicado no:Prostate Cancer Prostatic Dis
Main Authors: Sanchez, Alejandro, Schoenfeld, Jonathan D, Nguyen, Paul L, Fiorentino, Michelangelo, Chowdhury, Dipanjan, Stampfer, Meir J, Sesso, Howard D, Giovannucci, Edward, Mucci, Lorelei A, Shui, Irene M
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865401/
https://ncbi.nlm.nih.gov/pubmed/26926928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pcan.2016.4
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