ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway

Renal compensatory hypertrophy (RCH) restores normal kidney function after disease or loss of kidney tissue and is characterized by an increase in organ size due to cell enlargement and not to cell proliferation. In MDCK renal epithelial cells, silencing of the tight junction protein zona occludens...

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Publicado no:Mol Biol Cell
Main Authors: Domínguez-Calderón, Alaide, Ávila-Flores, Antonia, Ponce, Arturo, López-Bayghen, Esther, Calderón-Salinas, José-Víctor, Luis Reyes, José, Chávez-Munguía, Bibiana, Segovia, José, Angulo, Carla, Ramírez, Leticia, Gallego-Gutiérrez, Helios, Alarcón, Lourdes, Martín-Tapia, Dolores, Bautista-García, Pablo, González-Mariscal, Lorenza
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865316/
https://ncbi.nlm.nih.gov/pubmed/27009203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-08-0598
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