Generation and Improvement of Effector Function of a Novel Broadly Reactive and Protective Monoclonal Antibody against Pneumococcal Surface Protein A of Streptococcus pneumoniae

A proof-of-concept study evaluating the potential of Streptococcus pneumoniae Pneumococcal Surface Protein A (PspA) as a passive immunization target was conducted. We describe the generation and isolation of several broadly reactive mouse anti-PspA monoclonal antibodies (mAbs). MAb 140H1 displayed (...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kristian, Sascha A., Ota, Takayuki, Bubeck, Sarah S., Cho, Rebecca, Groff, Brian C., Kubota, Tsuguo, Destito, Giuseppe, Laudenslager, John, Koriazova, Lilia, Tahara, Tomoyuki, Kanda, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865217/
https://ncbi.nlm.nih.gov/pubmed/27171010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154616
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