Cell Line Derived 5-FU and Irinotecan Drug-Sensitivity Profiles Evaluated in Adjuvant Colon Cancer Trial Data

PURPOSE: This study evaluates whether gene signatures for chemosensitivity for irinotecan and 5-fluorouracil (5-FU) derived from in vitro grown cancer cell lines can predict clinical sensitivity to these drugs. METHODS: To test if an irinotecan signature and a SN-38 signature could identify patients...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Buhl, Ida Kappel, Gerster, Sarah, Delorenzi, Mauro, Jensen, Thomas, Jensen, Peter Buhl, Bosman, Fred, Tejpar, Sabine, Roth, Arnaud, Brunner, Nils, Hansen, Anker, Knudsen, Steen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865183/
https://ncbi.nlm.nih.gov/pubmed/27171152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155123
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