Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats

Mechanisms of restenosis in type 2 diabetes mellitus (T2DM) are incompletely elucidated, but advanced glycation end-product (AGE)-induced vascular remodeling likely contributes. We tested the hypothesis that AGE-related collagen cross-linking (ARCC) leads to increased downstream vascular resistance...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Wang, Hongfeng, Weihrauch, Dorothee, Kersten, Judy R., Toth, Jeffrey M., Passerini, Anthony G., Rajamani, Anita, Schrepfer, Sonja, LaDisa, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Vascular Biology and Microcirculation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865061/
https://ncbi.nlm.nih.gov/pubmed/26254329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00123.2014
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