Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine

Some schizophrenia patients are more sensitive to amphetamine (AMPH)-induced exacerbations in psychosis–an effect that correlates with higher striatal dopamine release. This enhanced vulnerability may be related to gamma-aminobutyric acid (GABA) deficits observed in schizophrenia. We hypothesized th...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Ahn, Kyung-Heup, Sewell, Andrew, Elander, Jacqueline, Pittman, Brian, Ranganathan, Mohini, Gunduz-Bruce, Handan, Krystal, John, D'Souza, Deepak Cyril
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864658/
https://ncbi.nlm.nih.gov/pubmed/25953357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.132
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