The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites

Despite the paradigm that carbohydrates are T cell-independent antigens, isotype-switched glycan-specific IgG antibodies and polysaccharide-specific T cells are found in humans. We employed a systems level approach combined with glycan array technology to decipher the repertoire of carbohydrate-spec...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Schneider, Christoph, Smith, David F., Cummings, Richard D., Boligan, Kayluz Frias, Hamilton, Robert G., Bochner, Bruce S., Miescher, Sylvia, Simon, Hans-Uwe, Pashov, Anastas, Vassilev, Tchavdar, von Gunten, Stephan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864610/
https://ncbi.nlm.nih.gov/pubmed/25568069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010524
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