Activity of Nitazoxanide and Tizoxanide against Mycobacterium tuberculosis in vitro and in whole blood culture

Nitazoxanide (NTZ) and its metabolite tizoxanide (TIZ) were studied as antimycobacterial agents in vitro (in mycobacterial growth indicator tube [MGIT] cultures) and in a whole blood bactericidal assay. Both NTZ and TIZ show high protein binding. In MGIT cultures (albumin concentration=78 µM), inhib...

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Опубликовано в: :Tuberculosis (Edinb)
Главные авторы: Harausz, Elizabeth P., Chervenak, Keith A., Good, Caryn E., Jacobs, Michael R., Wallis, Robert S., Sanchez-Felix, Manuel, Boom, W. Henry
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864490/
https://ncbi.nlm.nih.gov/pubmed/27156623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2016.03.002
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