Zygotes segregate entire parental genomes in distinct blastomere lineages causing cleavage-stage chimerism and mixoploidy

Dramatic genome dynamics, such as chromosome instability, contribute to the remarkable genomic heterogeneity among the blastomeres comprising a single embryo during human preimplantation development. This heterogeneity, when compatible with life, manifests as constitutional mosaicism, chimerism, and...

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Enregistré dans:
Détails bibliographiques
Publié dans:Genome Res
Auteurs principaux: Destouni, Aspasia, Zamani Esteki, Masoud, Catteeuw, Maaike, Tšuiko, Olga, Dimitriadou, Eftychia, Smits, Katrien, Kurg, Ants, Salumets, Andres, Van Soom, Ann, Voet, Thierry, Vermeesch, Joris R.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864459/
https://ncbi.nlm.nih.gov/pubmed/27197242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.200527.115
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