M4 muscarinic receptor signaling ameliorates striatal plasticity deficits in models of L-DOPA-induced dyskinesia

A balanced interaction between dopaminergic and cholinergic signaling in the striatum is critical to goal-directed behavior. But how this interaction modulates corticostriatal synaptic plasticity underlying learned actions remains unclear – particularly in direct-pathway spiny projection neurons (dS...

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Bibliographic Details
Published in:Neuron
Main Authors: Shen, Weixing, Plotkin, Joshua L., Francardo, Veronica, Ko, Wai Kin D, Xie, Zhong, Li, Qin, Fieblinger, Tim, Wess, Jürgen, Neubig, Richard R., Lindsley, Craig W., Conn, P. Jeffrey, Greengard, Paul, Bezard, Erwan, Cenci, M. Angela, Surmeier, D. James
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864040/
https://ncbi.nlm.nih.gov/pubmed/26590347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.10.039
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