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Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines

Increased activity of transcription factor NF-κB has been implicated in many B-cell lymphomas. We investigated effects of synthetic compound calafianin monomer (CM101) on biochemical and biological properties of NF-κB. In human 293 cells, CM101 selectively inhibited DNA binding by overexpressed NF-κ...

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Publicat a:Molecules
Autors principals: Yeo, Alan T., Chennamadhavuni, Spandan, Whitty, Adrian, Porco, John A., Gilmore, Thomas D.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863944/
https://ncbi.nlm.nih.gov/pubmed/25915462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules20057474
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