A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis.

Mutants of Chinese hamster ovary cells have been found that no longer produce heparan sulfate. Characterization of one of the mutants, pgsD-677, showed that it lacks both N-acetylglucosaminyl- and glucuronosyltransferase, enzymes required for the polymerization of heparan sulfate chains. pgsD-677 al...

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Bibliografske podrobnosti
Main Authors: Lidholt, K, Weinke, J L, Kiser, C S, Lugemwa, F N, Bame, K J, Cheifetz, S, Massagué, J, Lindahl, U, Esko, J D
Format: Artigo
Jezik:Inglês
Izdano: 1992
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC48638/
https://ncbi.nlm.nih.gov/pubmed/1532254
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