Analyzing Somatic Genome Rearrangements in Human Cancers by Using Whole-Exome Sequencing

Although exome sequencing data are generated primarily to detect single-nucleotide variants and indels, they can also be used to identify a subset of genomic rearrangements whose breakpoints are located in or near exons. Using >4,600 tumor and normal pairs across 15 cancer types, we identified ov...

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Udgivet i:Am J Hum Genet
Main Authors: Yang, Lixing, Lee, Mi-Sook, Lu, Hengyu, Oh, Doo-Yi, Kim, Yeon Jeong, Park, Donghyun, Park, Gahee, Ren, Xiaojia, Bristow, Christopher A., Haseley, Psalm S., Lee, Soohyun, Pantazi, Angeliki, Kucherlapati, Raju, Park, Woong-Yang, Scott, Kenneth L., Choi, Yoon-La, Park, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863662/
https://ncbi.nlm.nih.gov/pubmed/27153396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2016.03.017
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