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Landscape of Somatic Retrotransposition in Human Cancers

Transposable elements (TEs) are abundant in the human genome, and some are capable of generating new insertions through RNA intermediates. In cancer, the disruption of cellular mechanisms that normally suppress TE activity may facilitate mutagenic retrotranspositions. We performed single-nucleotide...

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Main Authors:	Lee, Eunjung, Iskow, Rebecca, Yang, Lixing, Gokcumen, Omer, Haseley, Psalm, Luquette, Lovelace J., Lohr, Jens G., Harris, Christopher C., Ding, Li, Wilson, Richard K., Wheeler, David A., Gibbs, Richard A., Kucherlapati, Raju, Lee, Charles, Kharchenko, Peter V., Park, Peter J.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2012
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3656569/ https://ncbi.nlm.nih.gov/pubmed/22745252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1222077
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Landscape of Somatic Retrotransposition in Human Cancers

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