Somatic Mutations in NEK9 Cause Nevus Comedonicus

Acne vulgaris (AV) affects most adolescents, and of those affected, moderate to severe disease occurs in 20%. Comedones, follicular plugs consisting of desquamated keratinocytes and sebum, are central to its pathogenesis. Despite high heritability in first-degree relatives, AV genetic determinants r...

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Bibliographic Details
Published in:Am J Hum Genet
Main Authors: Levinsohn, Jonathan L., Sugarman, Jeffrey L., McNiff, Jennifer M., Antaya, Richard J., Choate, Keith A.
Format: Artigo
Language:Inglês
Published: Elsevier 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863661/
https://ncbi.nlm.nih.gov/pubmed/27153399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2016.03.019
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