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New treatment options for ALK+ advanced non-small-cell lung cancer: critical appraisal of ceritinib

Rearrangements in ALK gene and EML4 gene were first described in 2007. This genomic aberration is found in about 2%–8% of non-small-cell lung cancer (NSCLC) patients. Crizotinib was the first ALK tyrosine kinase inhibitor licensed for the treatment of metastatic ALK-positive NSCLC based on a randomi...

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Vydáno v:Ther Clin Risk Manag
Hlavní autor: Rothschild, Sacha I
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863587/
https://ncbi.nlm.nih.gov/pubmed/27217763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/TCRM.S87876
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