Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.

The metabolic fate of the Alzheimer beta/A4 amyloid precursor protein (APP) includes intraamyloid proteolysis that leads to the production of secreted N-terminal and cell-associated C-terminal fragments. The cellular sites at which this processing occurs are not known. We have examined the route of...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Caporaso, G L, Gandy, S E, Buxbaum, J D, Greengard, P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48635/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1549591/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.6.2252
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