Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures

Genetic variants identified by genome-wide association studies explain only a modest proportion of heritability, suggesting that meaningful associations lie 'hidden' below current thresholds. Here, we integrate information from association studies with epigenomic maps to demonstrate that e...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wang, Xinchen, Tucker, Nathan R, Rizki, Gizem, Mills, Robert, Krijger, Peter HL, de Wit, Elzo, Subramanian, Vidya, Bartell, Eric, Nguyen, Xinh-Xinh, Ye, Jiangchuan, Leyton-Mange, Jordan, Dolmatova, Elena V, van der Harst, Pim, de Laat, Wouter, Ellinor, Patrick T, Newton-Cheh, Christopher, Milan, David J, Kellis, Manolis, Boyer, Laurie A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Genomics and Evolutionary Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862755/
https://ncbi.nlm.nih.gov/pubmed/27162171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10557
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