Receptor-Activator of Nuclear KappaB Ligand Expression as a New Therapeutic Target in Primary Bone Tumors

The receptor-activator of nuclear kappaB ligand (RANKL) signaling pathway plays an important role in the regulation of bone growth and mediates the formation and activation of osteoclasts. Osteoclasts are involved in significant bone resorption and destruction. Denosumab is a fully human monoclonal...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Yamagishi, Tetsuro, Kawashima, Hiroyuki, Ogose, Akira, Ariizumi, Takashi, Sasaki, Taro, Hatano, Hiroshi, Hotta, Tetsuo, Endo, Naoto
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862691/
https://ncbi.nlm.nih.gov/pubmed/27163152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154680
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